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A phase 1 trial enrolling participants with BMI 30–40 kg/m 2 and without T2D shows that when given in multiple ascending doses, the mean body weight losses by day 85 range from 7.2% to 14.5% at the lowest (140 mg) and highest (420 mg) doses, respectively, compared to weight gain of 1.5% for the placebo group (70)

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CMR is the method of choice for quantification of scar tissue compared with single-photon emission computed tomography owing to superior reproducibility and spatial resolution (18–20)